In many other cases, the determinants of linkage specificity and target protein selection remain elusive and are thus the subject of ongoing studies in my lab.
We also explore how binding partners affect the structure and conformational dynamics of ubiquitination enzymes to provide an additional layer of regulation.
Therefore, ubiquitination reactions in the cell ought to be highly specific.
At the University of California, Berkeley, my colleagues and I have uncovered the molecular mechanism of how one specific ubiquitin chain type (Lys11-linked chains) involved in cell cycle regulation is formed.
Research in my lab is directed at understanding the structural basis and functional consequences of posttranslational modifications.
Instagram even recently rolled out statuses via Instagram Direct, so you can also see exactly when your partner last opened the app.Cells need to regulate the abundance, the localization, and the activity of proteins in response to a myriad of stimuli.A major way to accomplish this challenging task is through posttranslational modifications.The potential of harnessing the ubiquitin system for therapeutic benefit has been widely recognized due to the clinical effectiveness of the proteasome inhibitor bortezomib (Velcade, Millennium Pharmaceuticals) in the treatment of multiple myeloma and mantle cell lymphoma, but is largely underexploited to date.Our research group is supported by the Emmy Noether Program of the German Research Foundation.